Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei
نویسندگان
چکیده
منابع مشابه
Differential expression of mitochondrial genes between life cycle stages of Trypanosoma brucei.
The mitochondrial respiratory system is differentially produced during the life cycle of the parasitic protozoan, Trypanosoma brucei. We have found 14 transcripts that are derived from a maxicircle (mitochondrial DNA) region that contains sequences homologous to cytochrome c oxidase subunits I and II, unassigned reading frame 1 from mitochondrial DNA of other organisms, and two other open readi...
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RNA editing is an essential post-transcriptional process that creates functional mitochondrial mRNAs in Kinetoplastids. Multiprotein editosomes catalyze pre-mRNA cleavage, uridine (U) insertion or deletion, and ligation as specified by guide RNAs. Three functionally and compositionally distinct editosomes differ by the mutually exclusive presence of the KREN1, KREN2 or KREN3 endonuclease and th...
متن کاملEditosome accessory factors KREPB9 and KREPB10 in Trypanosoma brucei.
Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites. We have identified here two new U1-like zinc finger proteins that associate with editosomes and have shown that they are related to KREPB6, KREPB7, and KREPB8, and thus we have named them Kinetoplastid RNA Editing Proteins, KR...
متن کاملComparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages
While gene expression is a fundamental and tightly controlled cellular process that is regulated at multiple steps, the exact contribution of each step remains unknown in any organism. The absence of transcription initiation regulation for RNA polymerase II in the protozoan parasite Trypanosoma brucei greatly simplifies the task of elucidating the contribution of translation to global gene expr...
متن کاملTbRGG2, an essential RNA editing accessory factor in two Trypanosoma brucei life cycle stages.
In the mitochondria of kinetoplastid protozoa, including Trypanosoma brucei, RNA editing inserts and/or deletes uridines from pre-mRNAs to produce mature, translatable mRNAs. RNA editing is carried out by several related multiprotein complexes known as editosomes, which contain all of the enzymatic components required for catalysis of editing. In addition, noneditosome accessory factors necessa...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2015
ISSN: 0021-9258
DOI: 10.1074/jbc.m115.669432